National Organization of Mothers of Twins Clubs, Inc - Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders

Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders

SUBJECTS NEEDED: 1. Children or adults who are twins or other multiples, or close brother or sister pairs (same parents and same gender) within four years of age, where one is well and one has a diagnosis of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and idiopathic inflammatory myopathy (IIM, meaning any form of adult or juvenile dermatomyositis, polymyositis or inclusion body myositis). The diagnosis of RA, SLE, SSc or IIM has to be within four years of enrollment. 2. Normal healthy volunteers, who do not have a blood relative with a rheumatic or autoimmune disease, and who are matched to enrolled patients, are also eligible to enroll in this study. Subjects may enroll at the NIH Clinical Center in Bethesda, Maryland, or at their local doctor’s offices. Patients remain under the care of their personal physicians while participating in the study. Medical records, questionnaires, blood and urine samples will be collected at enrollment and only a single visit is required. Subjects who develop new autoimmune diseases during the study will be asked to contact the study investigators. There is no charge for study-related evaluation and medical tests at the NIH. Compensation for enrollment is provided to each subject and referring physician.
LOCATION: Bethesda, Maryland
PURPOSE OF STUDY: Dr. Frederick Miller in the National Institute of Environmental Health Sciences, National Institutes of Health (NIH), is trying to understand the genetic and environmental factors that may result in systemic rheumatic diseases in his study titled “Pathogenic Studies in Families with Twins or Siblings Discordant for Systematic Rheumatic Disorders.” For more information on this study, please contact the NIH patient recruitment office at: Tel: 800-411-1222; 866-411-1010 (TTY); Email: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it .
INVESTIGATOR: Fredrick Miller, MD, PhD Clinical Research Program and Principal Investigator Office of Clinical Research NIEHS, NIH 900 Rockville Pik, NIH Bldg. 9 Rm 1W107 MSC 0958 Bethesda, MD, 20892 301-435-4515 Email: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
INITIATION DATE: July 2004	COMPLETION DATE: 2014
METHOD OF INVESTIGATION: Subjects may enroll at the NIH Clinical Center in Bethesda, Maryland, or at their local doctor’s offices. Patients remain under the care of their personal physicians while participating in the study. Medical records, questionnaires, blood and urine samples will be collected at enrollment and only a single visit is required. Subjects who develop new autoimmune diseases during the study will be asked to contact the study investigators. There is no charge for study-related evaluation and medical tests at the NIH. Compensation for enrollment is provided to each subject and referring physician.